Synthesis of Nanocomposites based on Mesoporous Aluminosilicate and Polyethyleneimine (PEI) for siRNA Delivery: Potential Usefulness of the Synergistic Effect of Al3+ Ion and PEI on the siRNA Delivery Efficiency for Diseases Treatment

Several nanocomposites based on Mesoporous Silica Nanoparticles (MSN), aluminum ions, and Polyethyleneimine (PEI) were synthesized by the combination of sol-gel post-synthesis methods. These mainly composed MSN with leading Al PEI species alone or in combination. The Al-MSN, MSN-PEI, Al-MSN/PEI samples characterized using FT-IR, XRD, SEM, EDX, zeta potential, nitrogen physisorption techniques. potential their RNA delivery was investigated loading releasing siRNA phosphate buffer. obtained results showed that capacity each sample is directly related to its potential. highest adsorption due possessing resulted presence high electric charge Al3+ cationic nature PEI. Under optimized conditions, amount 47.19 µg for 1.0 mg Al-MSN/PEI. exhibited yields 12, 20.4, 29.6, 36.0 % MSN, Al-MSN/PEI, respectively at room temperature 120 min.